Von Willebrand factor and ADAMTS13 in hemostasis and thrombosis (Part I)

Chairs: Ilaria Mancini (Italy), Karen Vanhoorelbeke (The Netherlands)

09.00

Von Willebrand factor self-association role in hemostasis and thrombosis
José Lopez (USA)

09.30

Interactions of von Willebrand factor/ADAMTS13
Jim Crawley (UK)

10.00

Modulation of ADAMTS13 conformation (open/close) in TTP
Karen Vanhoorelbeke (Belgium)

10.30

Impact of cohort studies on therapeutic approaches for von Willebrand disease  
Jeroen Eikenboom (The Netherlands)

11.00

Break

Von Willebrand factor and ADAMTS13 in hemostasis and thrombosis (Part II)

Chairs: Ilaria Mancini (Italy), Karen Vanhoorelbeke (Belgium)

11.30

Update on 3WINTERS
Augusto B. Federici (Italy)

12.00

Acquired von Willebrand disease  
Giancarlo Castaman (Italy)

12.30

Role of von Willebrand factor in the vessel wall: interplay with vascular smooth muscle cells
Cécile Denis (France)

13.00

Lunch

Oral Communications – von Willebrand Factor & ADAMTS 13

14.00

Von Willebrand factor (VWF) production and secretion, and endothelial cell characteristics in healthy ECFCs; Generating a valid ex vivo model for von Willebrand disease (VWD)
Suzan De Boer (The Netherlands)

Inhibition of ADAMTS13 prevents the loss of high molecular weight von Willebrand factor (VWF) multimers in an in vitro left ventricular assist device
Shannen Deconinck (Belgium)

Conformation of ADAMTS13 in the French cohort of child-onset thrombotic thrombocytopenic purpura
Bérangère Joly (France)

Patient anti-ADAMTS13 autoantibodies induce an open ADAMTS13 conformation in immune mediated thrombotic thrombocytopenic purpura
Elien Roose (France)

Tilting the balance: A trade-off between thrombotic thrombocytopenic purpura (TTP) patients autoantibody binding and proteolytic activity of ADAMTS13 variants
Nuno Alexandre Gomes Graca (The Netherlands)

In-depth epitope mapping of anti-ADAMTS13 autoantibodies in immune-mediated thrombotic thrombocytopenic purpura patients using a large library of ADAMTS13 fragments
Kadri Kangro (Belgium)

Other clinical challenges of hemophilia

Chairs: Massimo Morfini (Italy), Elena Santagostino (Italy)

15.00

Thrombosis in hemophilia: results from EUHASS Registry, including thrombotic microangiopathies
Mike Makris (UK)

15.30

Ageing with hemophilia
Pier Mannuccio Mannucci (Italy)

16.00

Eradication of HCV in Europe
Massimo Colombo (Italy)

16.30

Break

Immunotolerance induction in hemophilia (Part II)

Chairs: Sebastien Lacroix-Desmazes (France), Carmen Escuriola (Germany)

17.00

Gene-therapy-mediated tolerance induction
Valder R. Arruda (USA)

17.30

A working group on new concepts for ITI
Kate Pratt (USA)

18.00

End of the Conference