PROGRAMME

FRIDAY
17th SEPTEMBER
SATURDAY
18th SEPTEMBER
SUNDAY
19th SEPTEMBER

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THE PROGRAMME

ONSITELIVERECORDED

Gene therapy

Chairs: Brian O’Mahony (Ireland), Antonia Follenzi (Italy)

09:00

Gene therapy in haemophilia A and B: summary
David Lillicrap (Canada)

09:20

FVIII-induced endoplasmic reticulum (ER) stress in the context of gene therapy
Randal J. Kaufman (US)

09:40

Lentiviral factor VIII gene therapy: where we are standing
Alessio Cantore (Italy)

10:00

Discussion

Round table

Chairs: Flora Peyvandi (Italy), David Lillicrap (Canada)

10:10

Gene therapy: calculating the unknown
Discussants: Declan Noone (Ireland), Brian O’Mahony (Ireland), Glenn Pierce (US)

10:40

Coffee break

Haemophilia

Chairs: Peter Lenting (France), Angiola Rocino (Italy)

11:10

Engineering of novel factor VIII molecules: how we could improve the next molecules
Lindsey George (US)

11:30

Nanobodies as diagnostic and therapeutic tools in haemostasis
Peter Lenting (France)

11:50

Discussion

Satellite Lecture

12:00

Roche
PROGRAMME

Satellite Lecture

12:30

Sanofi Genzyme
PROGRAMME

13:00

Lunch

Satellite Symposium

14:00

Takeda
PROGRAMME

Oral Communications

Chairs: Cecile Denis (France), Augusto B. Federici (Italy)

15:00

Transplacental delivery of maternal maternal factor VIII for induction of maternal factor VIII-specific immune tolerance
Angelina Mimoun (France)

15:10

N-glycan shielded rhADAMTS13 for treatment of immune thrombotic thrombocytopenic purpura
Nuno A. G. Graça (The Netherlands)

15:20

Anti-cysteine/spacer autoantibodies that open the conformation of ADAMTS13 are a common feature of the autoimmune response in immune-mediated thrombotic thrombocytopenic purpura
Laure De Waele (Belgium)

15:30

From coagulation to angiogenesis: possible role of factor VIII in endothelial functionality
Cristina Olgasi (Italy)

15:40

Syntaxin 5 is essential for Golgi integrity, Weibel-Palade body biogenesis and stimulus-induced von Willebrand factor secretion from endothelial cells
Marije Kat (The Netherlands)

15:50

Developing a model for studying von Willebrand disease with hiPSC-derived endothelial cells
Suzan De Boer (The Netherlands)

16:00

Coffee break

16.30

E-POSTER SESSION
PROGRAMME

Non replacement therapies: novel drugs

Chairs: Jan Voorberg (The Netherlands)

17:30

Antithrombin knockdown: tipping the balance of haemostasis and thrombosis
Margaret V. Ragni (US)

17:50

Rebalancing haemostasis by inhibiting Activated Protein C (APC)
Jim Huntington (UK)

18:10

Discussion

18:20

Wrap up and closing remarks
Flora Peyvandi (Italy), Pier Mannuccio Mannucci (Italy)