PRELIMINARY PROGRAMME

Immune tolerance induction in haemophilia

Chairs: Giovanni Di Minno (Italy), Sebastien Lacroix-Desmazes (France)

09:00

CAR-T cell derived strategies for the induction of tolerance towards therapeutic factor VIII
Christoph Königs (Germany)

09:20

Maternal delivery of factor VIII to induce  factor VIII tolerance
Sebastien Lacroix-Desmazes (France)

09:40

Discussion

Thrombotic microangiopathies (TMAs) and atypical haemolytic uremic syndrome (aHUS)

Chairs: Giuseppe Remuzzi (Italy), Flora Peyvandi (Italy)

09:50

Novel aspects of pathophysiology, diagnosis, and treatment of transplant-associated TMA
Eleni Gavriilaki (Greece)

10:10

Old and new mechanisms for atypical HUS
Massimo Cugno (Italy)

10:30

Discussion

10:40

Coffee break

Remaining challenges in haemophilia

Chairs: Silvio Garattini (Italy), Pier Mannuccio Mannucci (Italy)

11:10

Immunogenicity of factor VIII products stemming from EUropean HAemophilia Safety Surveillance (EUHASS)
Kathelijn Fischer (The Netherlands)

11:30

Haemophilia and thrombosis – the gap is narrowing
Mike Makris (UK)

11:50

Discussion

Satellite Symposium

12:00

Novo Nordisk

13:00

Lunch

Satellite Symposium

14:00

Sobi and Sanofi Genzyme

Von Willebrand disease & von Willebrand factor

Chairs: Giancarlo Castaman (Italy), Augusto B. Federici (Italy)

15:00

Von Willebrand factor clearance: mechanisms and clinical impact
David Lillicrap (Canada)

15:20

Weibel-Palade bodies and regulation of von Willebrand factor size
Daniel Cutler (UK)

15:40

Discussion

15:50

Coffee break

16:20

Future therapies in von Willebrand disease: allele selective silencing of von Willebrand factor
Jeroen Eikenboom (The Netherlands)

16:40

Future therapies in von Willebrand disease: time for a tailored fit?
Caterina Casari (France)

17:00

Discussion

17.15

E-POSTER SESSION