Full programme
ADVANCES IN THROMBOTIC MICROANGIOPATHIES
Chairs: Paul Coppo (France), Nicola Ciavarella (Italy)
9:00-9:20
Challenges in the classification and nomenclature of different forms of microangiopathies
Marina Vivarelli (Italy)
9:20-9:40
Novel mechanism underlying the pathogenesis of immune thrombotic thrombocytopenic purpura (aTTP)
Long Zheng (US)
9:40-10:00
Anti von Willebrand factor therapies in immune thrombotic thrombocytopenic purpura (iTTP): now and then
Paul Coppo (France)
10:00-10:15
Discussion
KEYNOTE LECTURE
Chairs: Raimondo De Cristofaro (Italy)
10:15-10:40
The loss of tolerance in patients who previously underwent immune tolerance induction (ITI)
Sébastien Lacroix-Desmazes (France)
10:40-11:10
Coffee break
NEW INDICATIONS FOR BISPECIFIC ANTIBODIES
Chairs: Caterina Casari (France), Giancarlo Castaman (Italy)
11:10-11:30
Bispecific antibodies in acquired haemophilia A
Robert Klamroth (Germany)
11:30-11:50
Experimental and clinical rationale for the use of bispecific antibodies in von Willebrand disease
Caterina Casari (France)
11:50-12:00
Discussion
SATELLITE SYMPOSIUM
12:00-13:00
Sponsored by Sanofi
PROGRAMME
13:00-14:30
Lunch
SATELLITE LECTURE
14:30-15:00
Sponsored by BioMarin
PROGRAMME
ORAL COMMUNICATIONS:
LATEST ADVANCES PROPOSED BY THE INDUSTRY
Chairs: David Lillicrap (Canada), Sergio Siragusa (Italy)
15:00-15:10
Immunogenicity assessment of efanesoctocog alfa: results from the phase 3 XTEND-1 study
Christoph Königs (Germany)
15:10-15:20
Evaluation of the effect of early prophylactic corticosteroid administration with adeno- associated viral gene therapy in the haemophilia A dog model
David Lillicrap (Canada)
15:20-15:30
Sustained high level expression of FVII following AAV-mediated gene delivery in vivo
Andrea D’Amico (The Netherlands)
15:30-15:40
Interindividual variability of response to gene therapy in haemophilia B: ranges of factor IX increase after 24 months in HOPE-B etranacogene dezaparvovec trial
Steven Pipe (US)
15:40-16:30
E-POSTER SESSION
16:30-16:45
Coffee break
16:45-17:30
ROUND TABLE “Where are we and what will be the future of gene therapy?“
Chairs: Flora Peyvandi (Italy), Mike Makris (UK)
Discussants: Brian O’Mahony (Ireland), Glenn Pierce (US)
17:30
Wrap up and closing remarks
Flora Peyvandi (Italy), Pier Mannuccio Mannucci (Italy)